Mice are not cats: an (almost) exact proof.

We study the connectivity principles underlying the emergence of orientation selectivity in primary visual cortex (V1) of mammals lacking an orientation map. We present a computational model in which random connectivity gives rise to orientation selectivity that matches experimental observations. It predicts that orientation preference should shift with spatial frequency. We show evidence for such form dependent orientation tuning in mouse V1 using calcium imaging and intracellular whole cell recordings.

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